Laboratory of Excellence HepSYS 
Functional genomics of viral hepatitis and liver disease
 

JOB OFFERS 

 

New (july 2019)

 Scientist/project leader position in target and drug discovery for chronic liver disease and cancer using computational analyses and single cell RNASeq

A position as project leader and scientist is open at the Inserm Institute for Viral and Liver Disease (Inserm U1110) and the Laboratory of Excellence HepSYS (Head: Prof. Thomas F. Baumert, MD) at the University of Strasbourg, France. The institute is located in a state-of-the-art infrastructure and an internationally renowned research environment. Inserm and the University of Strasbourg are consistently ranked among the leading research organisations. The Baumert laboratory focuses on the investigation of the cell circuits driving chronic liver disease and cancer and the discovery and development of urgently needed preventive and therapeutic strategies(Aizarani et al. Nature 2019, Lupberger et al. Gastroenterology 2019, Hamdane et al. Gastroenterology 2019, Zhuang et al. Nature Comm 2019, Verrier et al. Cell Rep. 2016, Nakagawa et al. Cancer Cell 2016, Mailly et al. Nature Biotechnol. 2015). Research is funded by the European Commission (ERC AdG and PoC), Inserm, the French Cancer Association, the US National Institutes of Health and Pharma.

What we offer

You will lead a cutting-edge project to uncover key drivers of chronic liver disease and hepatocellular carcinoma allowing to discover novel therapeutic approaches using patient-derived tissues and organoids, single cell RNASeq and computational analyses. We provide the opportunity to work in a highly dynamic and international environment and a world-class network within top level research organisations, hospitals and pharma. Furthermore, we offer a competitive remuneration package, mentoring and long-term career opportunities within the Inserm and University of Strasbourg tenure-track program as well as our collaborating partners and pharma.

Profile

You are a highly motivated PhD or MD with a strong background in computational analyses of biological circuits and/or cell biology, have a solid track record of publications and are used to work in an international environment. MDs with interest in translational research are also encouraged to apply. You have excellent communication skills in written and spoken English. French is not required.

To apply, please send your motivation letter (why you are interested in this positionand long-term career goals) and CV (work experience and two references) to Prof. Thomas Baumert (Thomas.Baumert@unistra.fr) and Dr. Catherine Schuster (Catherine.Schuster@unistra.fr).

 

New (july 2019)

MD/PhD

PhD program in life science – human disease models for liver cancer

A three-year position for a PhD candidate is open at the Inserm Institute for Viral and Liver Disease (Inserm U1110) and the Laboratory of Excellence HepSYS (Head: Prof.Thomas F. Baumert, MD) at the University of Strasbourg, France. The institute is located in a state-of-the-art infrastructure and an internationally renowned research environment. Inserm and the University of Strasbourg are consistently ranked among the leading research organisations. The Baumert laboratory focuses on the investigation of the cell circuits driving chronic liver disease and cancer and the discovery and development of urgently needed preventive and therapeutic strategies(Aizarani et al. Nature 2019, Lupberger et al. Gastroenterology 2019, Hamdane et al. Gastroenterology 2019, Zhuang et al. Nature Comm 2019, Verrier et al. Cell Rep. 2016, Nakagawa et al. Cancer Cell 2016, Mailly et al. Nature Biotechnol. 2015). Research is funded by the European Commission (ERC AdG and PoC), Inserm, theFrench Cancer Association, the US National Institutes of Health and Pharma.

Offer :

Within our international PhD program you will develop and apply spheroids and organoids from human patient tissue to investigate the pathogenesis of chronic liver disease and cancer aiming to discover novel therapeutic targets. Your PhD program is embedded into the U Strasbourg Life Science Graduate School (head: Dr. Catherine Schuster) including a top-level graduate education in life sciences, tech transfer and biomedicine. We provide the opportunity to work in a highly dynamic and international environment and a world-class network within cutting-edge research organisations, hospitals and pharma.

Profil :

You are a highly motivated and curious graduate student with a completed MS. A solidbackground in cell biology and potentially computational analyses is desirable. MDs with interest in translational research are also encouraged to apply. You have excellent communication skills in written and spoken English. French is not required.

To apply, please send your motivation letter (why you are interested in the PhD program as well as mid-term career goals) and CV (work experience and two references) to Prof. Thomas Baumert (Thomas.Baumert@unistra.fr) and Dr. Catherine Schuster (Catherine.Schuster@unistra.fr).

 

Junior group leader

The Inserm Unit U1110, Institute for Viral and Liver Diseaseand the Laboratory of Excellence HepSYS (Head: Prof. Thomas F. Baumert, MD), University of Strasbourg, France is recruiting a junior group leader with an excellent track record and research interest in the study of virus-host interactions.

The unit offers an ideal internationally renowned research environment for the career development and evolution of researchers. A key focus area of the unit is the molecular investigation of virus-host interactions and their relevance for disease biology. Core aims of the research unit are the investigation of the mechanisms of virus-induced inflammation and cancer and to develop novel preventive or therapeutic approaches.

Junior group leaders that join our unit will benefit from our state-of-the-art infrastructure of the unit and a world-class scientific environment at Inserm and the University of Strasbourg. Financial support is possible through the LabEx HEPSYS, Inserm ATIP-AVENIR and the IDEX university programs. Furthermore, the candidate will have the opportunity to participate in the Inserm and University of Strasbourg faculty tenure track programs.

To apply, please send your CV (including experience, publications and academic references) and a brief statement of research interests to: Prof. Thomas Baumert (Thomas.Baumert@unistra.fr) and Catherine Corbel (Catherine.Corbel@unistra.fr).

 

Post-doctoral positions in functional genomics of virus-host interactions

Two EU ERC-funded post-doctoral positions are open at the Inserm Institute for Viral and Liver Disease (Inserm U1110) and the Laboratory of Excellence HepSYS (Head: Prof. Thomas F. Baumert, MD) at the University of Strasbourg, France. The institute is located in a state-of-the-art infrastructure and an internationally renowned research environment with all tech platforms on campus. Inserm and the University of Strasbourg are consistently ranked among the leading research organisations.

The Baumert laboratory focuses on the functional genomics of virus-host interactions to discover and develop novel preventive and therapeutic strategies for viral infection and liver disease (Colpitts et al. Gut 2017, Verrier et al. Cell Rep. 2016, Fauvelle et al. Gastroenterology 2016, Nakagawa et al. Cancer Cell 2016, Mailly et al. Nature Biotechnol. 2015; Majzoub et al. Cell 2014; Chung & Baumert N. Engl. J. Med. 2014; Zona et al. Cell Host Microbe 2013; Lupberger, Zeisel et al. Nature Med. 2011).

What we offer

Aiming to discover the cell circuits driving virus-induced disease biology and cancer, the successful candidates will focus on functional genomics of virus-host cell interactions. One position is open to apply CRISPR-Cas9 loss-of-function screens to uncover virus-induced disease biology using a novel human cell-based model system. A second position is open to develop novel humanized mouse models for virus-induced disease and cancer using AAV-mediated gene transfer and single cell RNASeq. We provide the opportunity to work in a highly dynamic and international environment with top-level collaborations within academia and industry. Furthermore we offer a competitive remuneration package, mentoring and long-term career opportunities within the Inserm tenure track program for junior faculty.

Profile

You are a highly motivated PhD or MD with a strong background in cell biology, virology or functional genomics (position 1) or animal experimentation (position 2) and have a solid track record of publications. You have excellent communication skills in written and spoken English. French is not required.

To apply, please send your motivation letter (why you are interested in this position) and CV (including experience, key publications and 3 academic references) to Prof. Thomas Baumert (Thomas.Baumert@unistra.fr) as well as the institute’s project manager Dr. Olga Koutsopoulos (koutsopoulos@unistra.fr).

 

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